Prologue is a practice for longevity. A physician oversees your protocol. The medications arrive at your door.
Prologue is a physician-led practice for longevity. When you join, a physician licensed in your state reviews your intake and prescribes a protocol when it is appropriate, and the practice stays with you between cycles. The practice handles your consultations and your care. The pharmacy ships your medications to your door at the prescribed cadence.
Your membership covers everything the practice does. Your medications are billed separately at member rates.
A complete foundation for your first year.
$129/ month
Month to month
Recommended for first-time patientsFor those who want more time with a physician.
$249/ month
Month to month
What they are, what’s hype, and what to ask before you start.
Read the guide
Glucose, insulin, muscle, and long-term foundations in the GLP-1 era.
Read the guide
VO₂ max, Zone 2, strength, body composition, and building a baseline.
Read the guide
Deep sleep, HRV, circadian rhythm, and recovery. Just the science.
Read the guideA physician who knows your name.
Your productive decades are getting longer. The science is settled on this. The medicine to support them has matured.
Prologue exists to help you build the foundation for those decades. Slowly, under the care of a physician who knows your name.
The work is patient. The horizon is long. We do not promise to fight time. We help you use it.
Each protocol begins with a physician evaluation and continues with ongoing physician oversight. Medications are compounded and shipped monthly. Begin where it makes sense for your biology.
Nine more medications are prescribed individually. See the full catalog
Keeping glucose and insulin in their healthy ranges has the deepest evidence base of any longevity intervention.
Metformin reduces glucose production in the liver. Acarbose slows carbohydrate absorption in the gut. Both have decades of safe use behind them.
It's the workout that progressively takes longer to recover from.
The sleep that looks fine but leaves you unrested. The afternoon where your thinking just slows. Two changes drive this, both beginning in your thirties: cellular NAD+ levels decline, and overnight growth hormone release weakens. NAD+ addresses the first. Sermorelin addresses the second.
Testosterone shapes energy, mood, body composition, cognition, and the quality of sleep.
Testosterone declines roughly one to two percent a year after thirty. The change accumulates for a decade before it's noticeable. A proper evaluation starts with a video consultation and confirmed testosterone levels. From there, physician-managed therapy, with the patience to adjust as your response shows up.
Start with reading. The free guides cover peptides, metabolic health, longevity fitness, and sleep. When you feel ready, the practice is open.
Choose your membership. Nothing is charged until a physician has approved your plan.
Your medical history and your goals, entered once. It becomes your file. Every Prologue physician reads it before they speak with you.
Your first visit is a video call. They arrive having already been through your intake, ready to talk through your goals and whether a protocol fits.
A protocol built for you, followed over time and adjusted as you respond. Your medications ship at the prescribed cadence.
The things people ask before they join. The rest are answered in full on the FAQ.
Join the practice. Nothing is charged until a physician has approved your plan.
