Deficiency, Corrected
The FDA approved them for exactly that, and the effect shows up in bloodwork.
Prescription · Clinical Monograph
B12 / B-complex
FDA-approved for B12 deficiency. Prologue prescribes it when a lab result shows you need it.
Vitamin B12 injections correct B12 deficiency. The FDA approved them for exactly that, and the effect shows up in bloodwork.
If your B12 is normal, injections do very little for your energy. That finding is old and consistent. It's the problem with B12 shots sold at wellness counters to people who were never tested.
Prologue prescribes it only when a test shows you need it.
Restores What Age Depletes
Adults over sixty, because stomach acid production falls and absorption follows.
Straight Past the Gut
Injection, because it bypasses the gut.
What getting it involves
A B12 result
A recent test that shows whether you are actually deficient.
A physician reads it
Against your history and your medications, not a threshold alone.
An approved indication
FDA-approved for B12 deficiency — the thing the test confirmed.
Dispensed
Injection, compounded by a licensed pharmacy partner.
Where the evidence stands
Solid
The evidence for correcting a deficiency is solid.
FDA-approved indication
Weak
The evidence for raising energy in someone whose B12 is already normal is weak, and has been for decades.
The useful question is whether you’re deficient, and bloodwork answers it.
Who tends to be deficient
Vegetarians and vegans
Because B12 comes from animal foods.
Adults over sixty
Because stomach acid production falls and absorption follows.
Anyone on a proton pump inhibitor
For the same reason — suppressing that acid is what the drug does.
People who’ve had bariatric surgery
Because the surgery changes how much the gut absorbs.
How it's prescribed
Injection, because it bypasses the gut. That matters for anyone whose deficiency comes from absorption rather than intake.
Your physician sets the schedule against your lab results.
Compounded by a licensed pharmacy partner and tested for potency, sterility, and endotoxin levels before shipment.
PotencySterilityEndotoxin
Disclosures
Vitamin B12 injection is FDA-approved for the treatment of B12 deficiency. It is compounded by a licensed pharmacy partner and tested for potency, sterility, and endotoxin levels before shipment. Treatment is not appropriate for every patient, and outcomes vary. Talk with your physician about whether this fits your situation.
Begin
How to get it.
B12 requires a consultation and a recent B12 result.
Everyone else starts by joining the practice.
Members can bring it up at their next consultation.
Questions
Nothing is charged when you join. Billing begins only after a physician has approved your plan. If they decide treatment isn't appropriate for you, you are not charged.
It is gentler than most people expect. The needle is the size of an insulin pen — thin and short, designed for subcutaneous tissue rather than muscle. Your physician can walk you through the technique at your consultation, and most patients are comfortable with the routine by the end of the first week.
NAD+ and sermorelin are compounded by a licensed pharmacy partner and shipped monthly with everything you need — vials, syringes, alcohol swabs, sharps disposal. Your physician adjusts dosing based on how you're responding.
It's a subcutaneous injection, given at home. Your physician sets the schedule, so the frequency is decided for you rather than fixed in advance.
The first dose takes about a minute. Your physician can walk you through the technique at your consultation, and you'll have everything you need in the first shipment.
Tell your physician at your intake. The needle is short and fine, and most people settle into the routine within the first couple of weeks — but if self-injection isn't workable for you, say so and your physician will talk through the alternatives.
For anything urgent, call 911 or your primary care physician — Prologue is not an emergency service. For everything else, write to the care team. Clinical questions get a reply within 24 hours.
Standard shipping for oral medications. Cold-chain shipping for injectables.
Protocol adjustments happen as your response shows up. If the dose or cadence changes, your next shipment reflects the change. There is no additional fee for protocol adjustments within your existing protocol.
Refills go out on the cadence your physician sets, without you having to ask.
Not listed here? Read the full FAQ.